It is unclear yet what led to the shooting, but police sources claim the Los Angeles woman was armed with a knife. Eyewitnesses, however, say the woman, who was homeless, did not have a knife.
The LA Police Department (LAPD) says officers responded to a call of an armed woman at 22nd and San Pedro streets around 9:30 a.m. on Sunday.
Paramedics were sent to the area at 9:42 a.m. and rushed the woman to a nearby hospital, where she died.
One of the two LAPD officers involved in the incident is a training officer while the other is a probationary officer.
Both are being placed on administrative leave as is standard protocol after any officer-involved shooting.
On Wednesday, a police officer in the US state of Maryland fatally shot an unarmed 19-year-old African American man as he allegedly tried to purchase narcotic medicine with a fake prescription.
Also, a video shot the same day showed US police officers fatally shooting a paralyzed black man in wheelchair in the State of Delaware.
The latest killings come amid growing sentiments against police violence against unarmed African-Americans in the past year.
Protests and riots have occurred across the US against police brutality and racial injustice since last summer.
Nearly 900 people have been killed by police since the beginning of 2015, according to data collected by an activist group known as Killed by Police.